替加氟
| CAS号 | 17902-23-7 | 货号 | BCP22714 |
| 中文名 | 替加氟 | ||
| 英文名 | Tegafur | ||
| 中文别名 | 呋氟嘧啶; | ||
| 英文别名 | Uftoral; Ftorafur; | ||
| 分子式 | C8H9FN2O3 | 分子量 | 200.17 |
| 生物活性 | Tegafur is a chemotherapeutic 5-FU prodrug used in the treatment of cancers. It is a component of tegafur-uracil. When metabolized, it becomes 5-FU. T egafur-uracil is a formulated therapeutic oral agent consisting of a combination of the 5-fluorouracil (5-FU) congener prodrug tegafur (tetrahydrofuranyl-5-fluorouracil) and uracil (1:4). The high concentration of uracil reversibly inhibits the uracil-reducing enzyme dihydropyrimidine dehydrogenase (DPD), thereby inhibiting first-pass DPD-mediated hepatic metabolism of the uracil analogue 5-FU and permitting administration of 5-FU as the orally bioavailable prodrug tegafur. Tegafur is bioactivated to 5-FU by liver microsomal cytochrome P450 enzymes. | ||
| 信号通路 | Cell Cycle/DNA Damage | ||
| 靶 点 | Antimetabolite | ||
结构式
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