AKT 蛋白激酶抑制剂IV
| CAS号 | 681281-88-9 | 货号 | BCP22722 |
| 中文名 | AKT 蛋白激酶抑制剂IV | ||
| 英文名 | Akt Inhibitor IV | ||
| 中文别名 | |||
| 英文别名 | AKTIV; AKT Inhibitor-IV; | ||
| 分子式 | C31H27N4S.I | 分子量 | 614.55 |
| 生物活性 | AKT Inhibitor IV promotes hyperphosphorylation of Akt (Protein kinase B), decreases phosphorylation of Akt substrates, and inhibits FOXO1a nuclear export (IC50 = 625 nM in PTEN-null cells). AKT Inhibitor IV inhibits the proliferation of several cells lines (IC50 values are <1.25 μM, 320 - 670 nM and 340 nM for 786-O, HeLa and Jurkat cells, respectively). This compound also displays broad antiviral activity against negative-stranded RNA viruses; inhibits replication of parainfluenza virus 5 (PIV5) in HeLa cells (IC50 = 520 nM). In HeLa cells, AKT Inhibitor IV accumulates in mitochondria, disrupting morphology and increasing ROS production. At high concentrations (10 μM), AKT Inhibitor IV activates the unfolded protein response and apoptosis in HEK293T cells. AKT Inhibitor IV is weakly fluorescent upon irradiation with UV light (excitation/emission maxima λ ~ 388/460; quantum yield = 0.0016). | ||
| 上下游产品 | 959841-49-7（(E)-Akt inhibitor-IV） | ||
| 信号通路 | PI3K/Akt/mTOR | ||
| 靶 点 | AKT | ||
结构式
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