PHT-427
| CAS No. | 1191951-57-1 | Cat. No. | BCP02902 |
| Name | PHT-427 | ||
| Synonyms | PHT427;PHT 427; | ||
| Formula | C20H31N3O2S2 | M. Wt | 409.61 |
| Description | PH-427 is a pleckstrin homology domain inhibitor to Akt/PDPK1. PH-427 significantly reduces phospho-Ser241-PDPK1 phospho-Thr308-Akt in PC-3 prostate cancer cells at 10 μM, which shows that PHT-427 could inhibit both Akt and PDPK1. PHT-427 also inhibits translocation of the Akt and PDPK1 PH domains in plasma membrane. [1] PHT-427 induces apoptosis and inhibits AKT phosphorylation with IC50 of 8.6 μM (in BxPC-3 cells), which mainly on its Ser473 residue and less strongly on Thr308 residue without affecting total Akt protein expression. PHT-427 also shows antiproliferation in Panc-1 cells with IC50 of 65 μM. | ||
| Pathways | PI3K/Akt/mTOR | ||
| Targets | AKT | ||
Structure
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