PF-573228
| CAS No. | 869288-64-2 | Cat. No. | BCP03672 |
| Name | PF-573228 | ||
| Synonyms | PF573228;PF 573228; | ||
| Formula | C22H20F3N5O3S | M. Wt | 491.49 |
| Description | PF 573228 blocks the phosphorylation of FAK Tyr397 in REF52 cells, PC3 cells, SKOV-3 cells, L3.6p1 and F-G, MDCK cells with IC50 of 30-500 nM. However, PF 573228 (1 μM) with 80% inhibition of FAK phosphorylation fails to inhibit cell growth or apoptosis. Similar treatment of cells with PF-228 resulted in inhibition of serum or FN-directed migration and decreased focal adhesion turnover | ||
| Pathways | Angiogenesis/Protein Tyrosine Kinase | ||
| Targets | FAK | ||
Structure
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