Tirapazamine

  • Chemical Properties
CAS No. 27314-97-2 Cat. No. BCP03663
Name Tirapazamine
Synonyms WIN-59075; WIN 59075; SR 259075;SR-259075;SR259075;SR4233;SR 4233;SR-4233;Tirazone;Win59075;NSC130181;NSC-130181;NSC 130181;
Formula C7H6N4O2 M. Wt 178.15
  • Biological Activity
Description Tirapazamine is a benzotriazine di-N-oxide with potential antineoplastic activity. Tirapazamine is selectively activated by multiple reductases to form free radicals in hypoxic cells, thereby inducing single-and double-strand breaks in DNA, base damage, and cell death. This agent also sensitizes hypoxic cells to ionizing radiation and inhibits the repair of radiation-induced DNA strand breaks via inhibition of topoisomerase II. Check for active clinical trials or closed clinical trials using this agent.
Pathways Others Pathway 
Targets Others 

Structure

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