Rofecoxib

Description	Rofecoxib is a synthetic, nonsteroidal derivative of phenyl-furanone with antiinflammatory, antipyretic and analgesic properties and potential antineoplastic properties. Rofecoxib binds to and inhibits the enzyme cyclooxygenase-2 (COX-2), resulting in an inhibition of the conversion of arachidonic acid to prostaglandins. COX-related metabolic pathways may represent key regulators of cell proliferation and neo-angiogenesis. Some epithelial tumor cell types overexpress pro-angiogenic COX-2. Rofecoxib was used as an anti-inflammatory analgesic which has now been withdrawn from the market because of its association with cardiovascular problems.
Pathways	Neuro Signaling Pathway
Targets	COX

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