KX2-391 dihydrochloride

CAS No.	1038395-65-1	Cat. No.	BCP03485
Name	KX2-391 dihydrochloride
Synonyms	KX2-391 2HCl; Tirbanibulin dihydrohcloride;
Formula	C26H29N3O3.2(HCl)	M. Wt	504.46

Description	KX2-391 is a Src inhibitor that is directed to the Src substrate pocket. KX2-391 shows steep dose-response curves against Huh7 (GI 50 = 9 nM), PLC/PRF/5 (GI 50 = 13 nM), Hep3B (GI 50 = 26 nM), and HepG2 (GI 50 = 60 nM), four hepatic cell cancer (HCC) cell lines.KX2-391 is found to inhibit certain leukemia cells that are resistant to current commercially available drugs, such as those derived from chronic leukemia cells with the T3151 mutation. KX2-391 is evaluated in engineered Src driven cell growth assays inNIH3T3/c-Src527F and SYF/c-Src527F cells and exhibits GI50 with 23 nM and 39 nM, respectively.
Pathways	Angiogenesis/Protein Tyrosine Kinase Cell Cycle/DNA Damage
Targets	Microtubule Src/Bcr Abl

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