AM580

  • Chemical Properties
CAS No. 102121-60-8 Cat. No. BCP03051
Name AM580
Synonyms AM-580;AM 580;
Formula C22H25NO3 M. Wt 351.44
  • Biological Activity
Description Studies indicate that RARα increases the signaling of the RARα receptor to prevent intracellular and extracellular Amyloid β accumulation. In addition, this receptor increases the expression of disintegrin and metalloprotease. Since Amyloid β accumulation is a major finding in Alzheimer's disease (AD), AM 580 can be used to study this disease in vitro. AM 580 also induces the functions of IL-4, IL-5 and IL-13 and suppresses the production of IL-12 and IFNγ. Alternate studies suggest that AM 580 inhibits tumor proliferation, via reducing the level of RARγ. AM 580 is an activator of RAR β and RAR γ.
Pathways Protease/Metabolic Enzyme 
Targets RAR/RXR 

Structure

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