AM580
CAS No. | 102121-60-8 | Cat. No. | BCP03051 |
Name | AM580 | ||
Synonyms | AM-580;AM 580; | ||
Formula | C22H25NO3 | M. Wt | 351.44 |
Description | Studies indicate that RARα increases the signaling of the RARα receptor to prevent intracellular and extracellular Amyloid β accumulation. In addition, this receptor increases the expression of disintegrin and metalloprotease. Since Amyloid β accumulation is a major finding in Alzheimer's disease (AD), AM 580 can be used to study this disease in vitro. AM 580 also induces the functions of IL-4, IL-5 and IL-13 and suppresses the production of IL-12 and IFNγ. Alternate studies suggest that AM 580 inhibits tumor proliferation, via reducing the level of RARγ. AM 580 is an activator of RAR β and RAR γ. | ||
Pathways | Protease/Metabolic Enzyme | ||
Targets | RAR/RXR |
Structure
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