Clomifene citrate

CAS No.	50-41-9	Cat. No.	BCP03057
Name	Clomifene citrate
Synonyms	Clomid;Serophene;Milophene;Serophene;
Formula	C26H28ClNO.C6H8O7	M. Wt	598.08

Description	Clomifene Citrate(CC) acted as an estrogen antagonist regardless of the concentration of E2 added together. In conclusion, CC acts as an estrogen agonist/antagonist via ER alpha in a coexisting estrogen concentration-dependent way whereas it acts as an estrogen antagonist via ER beta whether or not estrogen is present . Clomiphene was effective in increasing pregnancy rate compared to placebo (OR 5.8, 95% CI 1.6 to 21.5) as was clomiphene plus dexamethasone treatment (OR 9.46, 95% CI 5.1 to 17.7) compared to clomiphene alone. A significant improvement in the pregnancy rate was reported for clomiphene plus combined oral contraceptives versus clomiphene alone. No evidence of a difference in effect on pregnancy rate was found with any of the other comparisons .
Pathways	Hormone Pathay
Targets	Estrogen Receptor

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