Azelastine HCl

CAS No.	79307-93-0	Cat. No.	BCP23404
Name	Azelastine HCl
Synonyms	Allergodil；Azelastine hydrochloride;
Formula	C22H24ClN3O.HCl	M. Wt	418.36

Description	Azelastine HCl is a potent and selective H1-receptor antagonist, with antiallergic effects related to histamine antagonism, and further antiallergic and anti-inflammatory effects unrelated to H1-receptor binding. Azelastine HCl is an activator of NF-kB activator. Azelastine hydrochloride has been used in a study to investigate the potential of polymeric microspheres for treatment of allergic conjunctivitis. Azelastine is shown to block secretion of IL-6, IL-8, and TNF alpha from mast cells by inhibiting NF-κB activation.
Pathways	Neuro Signaling Pathway GPCR/G Protein
Targets	Histamine Receptor

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