Flucytosine
| CAS No. | 2022-85-7 | Cat. No. | BCP02877 |
| Name | Flucytosine | ||
| Synonyms | 5-fluorocytosine;Ancotil;Ancotyl;Flucytosin;NSC 103805;NSC-103805;NSC103805;Ro 2-9915;Ro2-9915;Ancobon; | ||
| Formula | C4H4FN3O | M. Wt | 129.09 |
| Description | Flucytosine inhibits the growth of C. neoformans in Sabouraud's dextrose broth at concentrations ≥ 1.25 mg/L, and Flucytosine of 50 mg/L causes a ~50% reduction in colony-forming unit (cfu)\ in the J774.16 killing assay with viability of J774.16 cells not affected measured by trypan blue exclusion. The combination of Flucytosine and IgGl monoclonal antibody to Cryptococcus neoformans capsular glucuronoxylomannan is more effective in reducing the numbers of C. neoformans colony-forming units in vitro with J774.16 murine macrophage-like cells than either agent alone. The efficacy of Flucytosine (5FC) in combination with amphotericin B (AB) and fluconazole (FCZ) is studied against 35 yeast isolates, of which the 5FC-FCZ combination is antagonistic against Candida species, but for some Candida isolates synergism is found. | ||
| Pathways | Microbiology/Virology | ||
| Targets | Antifungal | ||
Structure
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