GDC-0879
| CAS No. | 905281-76-7 | Cat. No. | BCP02896 |
| Name | GDC-0879 | ||
| Synonyms | GDC0879;GDC 0879; | ||
| Formula | C19H18N4O2 | M. Wt | 334.37 |
| Description | GDC-0879 also inhibits cellular pERK with IC50 of 63 nM. GDC-0879 shows comparable potency in A375 melanoma and Colo205 colorectal carcinoma cell lines, both of which are B-RafV600E mutant, with IC50 of 59 nM and 29 nM for pMEK1 inhibition respectively. GDC-0879 potently inhibits B-RafV600E in Malme3M cells with IC50 of 0.75 μM. GDC-0879 also shows EC50 values < 0.5 μM in many tumor cells (A375, 624, SK-MEL-28, Malme3M, C32, 928, 888, G-361, Colo205, Colo206, SW1417, CL34, and Colo201). | ||
| Pathways | MAPK Pathway | ||
| Targets | Raf | ||
Structure
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