Triciribine phosphate
| CAS No. | 61966-08-3 | Cat. No. | BCP02904 |
| Name | Triciribine phosphate | ||
| Synonyms | VQD-002; VQD 002; VQD002; TCN-P;NSC-280594;NSC 280594;NSC280594; | ||
| Formula | C13H17N6O7P | M. Wt | 400.28 |
| Description | Triciribine Phosphate is the phosphate salt of the synthetic, cell-permeable tricyclic nucleoside triciribine with potential antineoplastic activity. Triciribine inhibits the phosphorylation, activation, and signalling of Akt-1, -2, and -3, which may result in the inhibition of Akt-expressing tumor cell proliferation. Akts are anti-apoptotic serine/threonine-specific protein kinases that phosphorylate and inactivate components of the apoptotic machinery, including Bcl-xL/Bcl-2-associated death promoter (BAD) and caspase 9. | ||
| Pathways | Cell Cycle/DNA Damage Microbiology/Virology PI3K/Akt/mTOR | ||
| Targets | DNA/RNA Synthesis HIV AKT | ||
Structure
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