Procarbazine hydrochloride

CAS No.	366-70-1	Cat. No.	BCP02880
Name	Procarbazine hydrochloride
Synonyms	Matulane;Nsc-77213;Nsc 77213;Nsc77213;
Formula	C12H19N3O.HCl	M. Wt	257.76

Description	The mechanism of action is not fully understood. Metabolism yields azo-procarbazine and hydrogen peroxide which results in the breaking of DNA strands.Exposure to procarbazine hydrochloride by intraperitoneal injection caused tumors in rats and mice at several different tissue sites. In both rats and mice, it caused cancer of the brain (olfactory neuroblastoma) and hematopoietic system (lymphoma in rats and lymphoma or leukemia in mice). In rats, it also caused mammary-gland cancer (adenocarcinoma) in both sexes. In mice, it also caused benign lung tumors (adenoma) in both sexes and uterine cancer (adenocarcinoma) in females. Procarbazine hydrochloride is an oral alkylating agent primarily used as a component of chemotherapy regimens for Hodgkin's lymphoma, as well as in regimens for primary central nervous system lymphoma and high-grade gliomas. After discontinuation of all drug therapy, exclusion of other potential etiologies, and resolution of hepatic injury, the patient was rechall
Pathways	Cell Cycle/DNA Damage
Targets	DNA Alkylator/Crosslinker

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