Ritonavir
| CAS No. | 155213-67-5 | Cat. No. | BCP02905 |
| Name | Ritonavir | ||
| Synonyms | Norvir;Norvir Softgel;ABT 538; ABT-538; ABT538; RTV; | ||
| Formula | C37H48N6O5S2 | M. Wt | 720.94 |
| Description | Ritonavir is a very potent inhibitor of CYP3A4 mediated testosterone 6β-hydroxylation with mean Ki of 19 nM and also inhibits tolbutamide hydroxylation with IC50 of 4.2 μM.Ritonavir is found to be a potent inhibitor of CYP3A-mediated biotransformations (nifedipine oxidation with IC50 of 0.07 mM, 17alpha-ethynylestradiol 2-hydroxylation with IC50 of 2 mM; terfenadine hydroxylation with IC50 of 0.14 mM). Ritonavir is also found to be an inhibitor of the reactions mediated by CYP2D6 (IC50 = 2.5 mM) and CYP2C9/10 (IC50 = 8.0 mM). Ritonavir results in an increase in cell viability in uninfected human PBMC cultures. Ritonavir markedly decreases the susceptibility of PBMCs to apoptosis correlated with lower levels of caspase-1 expression, decreases in annexin V staining, and reduces caspase-3 activity in uninfected human PBMC cultures. Ritonavir inhibits induction of tumor necrosis factor (TNF) production by PBMCs and monocytes in a time- and dose-dependent manner at nontoxic concentrations. | ||
| Pathways | Protease/Metabolic Enzyme Microbiology/Virology | ||
| Targets | HIV Protease HIV | ||
Structure
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