Lacidipine

Description	Lacidipine (Lacipil, Motens) also inhibits Ca2+ (ER) efflux and enhances folding, trafficking, and activity of degradation-prone GC variants. Lacidipine (Lacipil, Motens) remodels mutated GC proteostasis by simultaneously activating a series of distinct molecular mechanisms, namely modulation of Ca2+ homeostasis, upregulation of the ER chaperone BiP, and moderate induction of the unfolded protein response. However, unlike previously reported proteostasis regulators, lacidipine (Lacipil, Motens) treatment is not cytotoxic but inhibits apoptosis induction typically associated with sustained activation of the unfolded protein response.In another study, lacidipine pre-treatment prevents deterioration of motor nerve conduction velocity as compared to streptozotocin diabetic rats. Hyperalgesia induces by streptozotocin was antagonized by lacidipine (Lacipil, Motens).
Pathways	Ion Channel/Membrane Transporter
Targets	Calcium Channel

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