R-5-Hydroxymethyl Tolterodine

CAS No.	207679-81-0	Cat. No.	BCP02922
Name	R-5-Hydroxymethyl Tolterodine
Synonyms	PNU 200577;Desfesoterodine;PNU-200577;5-HMT;5-HM;
Formula	C22H31NO2	M. Wt	341.49

Description	5-hydroxymethyl tolterodine is a major pharmacologically active metabolite of tolterodine. 5-hydroxymethyl tolterodine produces a competitive and concentration-dependent inhibition of carbachol-induced contraction of guinea-pig isolated urinary bladder strips. 5-hydroxymethyl tolterodine antagotizes muscarinic receptors with a pA2 of 9.1. 5-hydroxymethyl tolterodine causes a concentration-dependent inhibition of (-)3 H-QNB binding in homogenates of guinea-pig urinary bladder, parotid gland, heart and cerebral cortex.5-hydroxymethyl tolterodine has a similar pharmacological profile with tolterodine. Intravenous infusion of 5-hydroxymethyl tolterodine produces a dose-dependent inhibition of the intravesical volume-induced urinary bladder contraction measured as the micturition pressure.
Pathways	Neuro Signaling Pathway GPCR/G Protein
Targets	mAChR

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