Fludarabine Phosphate
| CAS No. | 75607-67-9 | Cat. No. | BCP02872 |
| Name | Fludarabine Phosphate | ||
| Synonyms | Fludara;-F-ara-AMP;FAMP; | ||
| Formula | C10H13FN5O7P | M. Wt | 365.21 |
| Description | Fludarabine Phosphate is converted to F-ara-ATP in cells and then incorporated into DNA in a self-limiting manner. Fludarabine Phosphate competes with dATP for incorporation into the A site of the extending DNA strand, which results in termination of DNA strand elongation. Human DNA polymerase α incorporates more Fludarabine Phosphate into DNA than polymerase δ. Fludarabine Phosphate completively inhibits DNA polymerase α and DNA polymerase δ with Ki of 1.1 μM and 1.3 μM, respectively. DNA polymerase δ is also able to excise the incorporated Fludarabine Phosphate from DNA in vitro. | ||
| Pathways | Cell Cycle/DNA Damage | ||
| Targets | Antimetabolite | ||
Structure
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