Sodium valproate

CAS No.	1069-66-5	Cat. No.	BCP02888
Name	Sodium valproate
Synonyms	Depakene;Valrelease;Valproic acid sodium salt;Sodium valproate;
Formula	C8H15NaO2	M. Wt	166.19

Description	in vitro: Valproic acid had the effect on the growth and death of HeLa cervical cancer cells in relation to reactive oxygen species (ROS) and glutathione (GSH). Dose- and time-dependent growth inhibition was observed in HeLa cells with an IC50 of approximately 10 mM at 24 h. DNA flow cytometric analysis indicated that 10 mM VPA induced a G2/M phase arrest of the cell cycle. This agent also induced apoptosis, which was accompanied by the cleavage of PARP, the activation of caspase-3, -8 and -9, and the loss of mitochondrial membrane potential (MMP; ?Ψm). All the tested caspase inhibitors significantly prevented HeLa apoptotic cell death induced by VPA, whereas TNF-α intensified the apoptotic cell death [1]. Valproic acid downregulated HDAC, increased histone H3 acetylation and enhanced the accumulation of hyperacetylated histone H3 on the VEGF promoters. in vivo: Pregnant Long Evans rats were injected with 350mg/kg VPA or saline on gestational day 13. A modified social interaction test
Pathways	Cell Cycle/DNA Damage Epigenetics
Targets	HDAC

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