Tetrandrine
| CAS No. | 518-34-3 | Cat. No. | BCP02934 |
| Name | Tetrandrine | ||
| Synonyms | Hanfangchin A;NSC 77037;Fanchinine;S,S-(+)-Tetrandrine;Sinomenine A;TTD;Tetrandrin;d-Tetrandr; | ||
| Formula | C38H42N2O6 | M. Wt | 622.75 |
| Description | Tetrandrine inhibits voltage-gated Ca2+ currents with an IC50 of 10.1 mM in isolated nerve terminals of the rat neurohypophysis. Tetrandrine is a high-affinity blocker of the type II, maxi-Ca(2+)-activated K+ channel of the rat neurohypophysial terminals with an IC50 of 0.21 mM. Another study shows that Tetrandrine also inhibits Ca(2+)-activated Cl- currents (I(Cl,Ca)) with an IC50 of 5.2 mM. Tetrandrine inhibits the proliferation of human leukemic HL-60 cells via induction of apoptosis. | ||
| Pathways | Ion Channel/Membrane Transporter | ||
| Targets | Potassium Channel Calcium Channel | ||
Structure
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