NSC-207895
| CAS No. | 58131-57-0 | Cat. No. | BCP23434 |
| Name | NSC-207895 | ||
| Synonyms | XI-006;XI 006;XI006;NSC 207895;NSC207895; | ||
| Formula | C11H13N5O4 | M. Wt | 279.25 |
| Description | NSC207895 is a cell-permeable benzofuroxan compound that downregulates the p53 negative regulator MDMX protein level in MCF-7, LNCaP, and A549 cells (1 to 10 µM for 16 to 24 h) by suppressesing MDMX promoter transcription activity (IC50 = 2.5 µM in HT1080 cells), leading to enhanced p53 stabilization and activation. | ||
| Pathways | Apoptosis Pathway | ||
| Targets | Mdm2 | ||
Structure
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