WAY-600
| CAS No. | 1062159-35-6 | Cat. No. | BCP02897 |
| Name | WAY-600 | ||
| Synonyms | WAY 600;WAY600; | ||
| Formula | C28H30N8O | M. Wt | 494.59 |
| Description | Immune-complex kinase assay shows mTORC2-specific substrate His6-AKT or the mTORC1 substrate His6-S6K is dose dependently inhibited by WAY-600. WAY-600 globally inhibits mTOR signaling and AKT function in cellular models dose dependently. WAY-600 profoundly inhibits cap-dependent and global protein synthesis in MDA361, human breast cancer cells. WAY-600 shows antiproliferative effects in various cancer cell lines involving G1 cell cycle arrest and selective apoptosis. WAY-600 down-regulate angiogenic factors, VEGF and HIF-1α, in U87MG, MDA361 and LNCap cells. | ||
| Pathways | PI3K/Akt/mTOR | ||
| Targets | mTOR | ||
Structure
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