Flavopiridol hydrochloride

CAS No.	131740-09-5	Cat. No.	BCP02854
Name	Flavopiridol hydrochloride
Synonyms	HL 275;NSC 649890;MDL 107826A;FLAVOPIRIDOL HCL; Alvocidib Hydrochloride;
Formula	C21H20ClNO5.HCl	M. Wt	438.3

Description	Flavopiridol is initially found to inhibit the epidermal growth factor receptor and protein kinase A (IC50 = 21 and 122 μM). Flavopiridol is later shown to inhibit cell proliferation, at more physiologically relevant concentrations (IC50 = 66 nM) when Flavopiridol is tested in the National Cancer Institute Development Therapeutics Program panel of 60 human tumor cell lines.Flavopiridol induces G1 arrest with inhibition of CDK2 and CDK4 in human breast carcinoma cells in a time and concentration dependent manner.Short time treatment of Flavopiridol (~12 hours) induce apoptosis in hematopoietic cell lines including SUDHL4, SUDHL6 (B-cell lines), Jurkat and MOLT4 (T-cell lines ), and HL60 (myeloid). In the clonogenic assay, Flavopiridol functions as a highly potent cytotoxic compound with a mean IC70 with 8 ng/mL in 23 human tumor models. A recent study shows Flavopiridol treatment induces a substantial AKT-Ser473 phosphorylation in human glioblastoma T98G cell line.
Pathways	Cell Cycle/DNA Damage
Targets	CDK

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