GSK-189254 hydrochloride
| CAS号 | 945493-87-8 | 货号 | BCP23443 |
| 中文名 | GSK-189254 hydrochloride | ||
| 英文名 | GSK-189254 hydrochloride | ||
| 中文别名 | |||
| 英文别名 | GSK 189254A; GSK189254A; GSK-189254A; GSK 189254 HCl; | ||
| 分子式 | C21H25N3O2.HCl | 分子量 | 387.91 |
| 生物活性 | GSK-189,254 is a potent and selective H3-receptor inverse agonist developed by GlaxoSmithKline. It has subnanomolar affinity for the H3 receptor (Ki 0.2nM) and selectivity of over 10,000x for H3 over other histamine receptor subtypes.Animal studies have shown it to possess not only stimulant and nootropic effects, but also analgesic action suggesting a role for H3 receptors in pain processing in the spinal cord. GSK-189,254 and several other related drugs are currently being investigated as a treatment for Alzheimer's disease and other forms of dementia, as well as possible use in the treatment of conditions such as narcolepsy, or neuropathic pain which do not respond well to conventional analgesic drugs. | ||
| 信号通路 | Neuro Signaling Pathway GPCR/G Protein | ||
| 靶 点 | Histamine Receptor | ||
结构式
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