H-89
| CAS号 | 127243-85-0 | 货号 | BCP02706 |
| 中文名 | H-89 | ||
| 英文名 | H-89 | ||
| 中文别名 | |||
| 英文别名 | H 89;H89;H-89 2HCl;H-89 DIHYDROCHLORIDE; | ||
| 分子式 | C20H20BrN3O2S | 分子量 | 446.36 |
| 生物活性 | H89 2HCl is a potent PKA (cAMP-dependent) protein kinase A inhibitor with Ki of 48 nM, exhibits 10-fold selectivity over PKG, exhibits >500-fold selectivity over PKC, MLCK, calmodulin kinase II and casein kinase I/II. Pretreatment of the cells with H-89 (30 μM) 1 h before the addition of forskolin markedly inhibits the forskolin-induced protein phosphorylation in a dose-dependent manner.H89 also inhibits several other kinases with IC50 of 80, 120, 135, 270, 2600 and 2800 nM for S6K1, MSK1, PKA, ROCKII, PKBα and MAPKAP-K1b, respectively. H89 also has activity at some cellular receptors and ion channels, including Kv1.3 K+ channels,β1AR and β2AR. | ||
| 信号通路 | GPCR/G Protein Wnt/Stem Cell | ||
| 靶 点 | PKA | ||
结构式
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