GSK256066
| CAS No. | 801312-28-7 | Cat. No. | BCP02627 |
| Name | GSK256066 | ||
| Synonyms | GSK-256066;GSK 256066; | ||
| Formula | C27H26N4O5S | M. Wt | 518.58 |
| Description | GSK256066 is a slow and tight binding inhibitor of PDE4B with apparent IC50 of 3.2 pM. GSK256066 is an extremely potent inhibitor of LPS-stimulated TNFα production in PBMCs with pIC50 of 11.0 and IC50 of 10 pM and human whole-blood cultures with pIC50 of 9.90 and IC50 of 126 pM. GSK256066 is highly selective for PDE4 (>3.8 × 105-fold versus PDE1, PDE2, PDE3, PDE5, and PDE6 and >2.5 × 103-fold against PDE7). GSK256066 inhibits PDE4 isoforms A-D with equal affinity. | ||
| Pathways | Protease/Metabolic Enzyme | ||
| Targets | Phosphodiesterase/PDE | ||
Structure
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