GDC0980
CAS No. | 1032754-93-0 | Cat. No. | BCP02622 |
Name | GDC0980 | ||
Synonyms | GDC-0980;GDC 0980;RG 7422;RG-7422;RG7422; GNE 390; GNE-390; GNE390; Apitolisib; | ||
Formula | C23H30N8O3S | M. Wt | 498.6 |
Description | GDC-0980 shows the potent and selective inhibitory activities against class I PI3K and mTOR kinase versus a large panel of kinases with Ki of 17 nM for mTOR and IC50 of 5 nM, 27 nM, 7 nM, and 14 nM for PI3Kα, β, δ, and γ, respectively.In vitro, GDC-0980 significantly inhibits cell proliferation in PC3 and MCF7 cells with IC50 of 307 nM and 255 nM, respectively. A recent study shows that GDC-0980 reduces cancer cell viability by inhibiting cell-cycle procession and inducing apoptosis with most potency in prostate (IC50 < 200 nM 50%), <500 nM 100%), breast (IC50 <200 nM 37%, <500 nM 78%) and NSCLC lines (IC50 <200 nM 29%, <500 nM 88%) and less potency in pancreatic (IC50 <200 nM 13%, <500 nM 67%) and melanoma cell lines (IC50 <200 nM 0%, <500 nM 33%). | ||
Pathways | PI3K/Akt/mTOR | ||
Targets | PI3K mTOR |
Structure
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