Torin 2
| CAS号 | 1223001-51-1 | 货号 | BCP02612 |
| 中文名 | Torin 2 | ||
| 英文名 | Torin 2 | ||
| 中文别名 | |||
| 英文别名 | Torin2; Torin-2; | ||
| 分子式 | C24H15F3N4O | 分子量 | 432.4 |
| 生物活性 | Torin 2 has the same binding mode as PI3Kγ, V882 serves as a hinge binding point and in the inner hydrophobic pocket Y867, D841 and D964 provide three more hydrogen bonds with aminopyridine side chain analogous to Y2225, D2195 and D2357 of mTOR.Torin 2 inhibits mTORC1, thus activates TFEB by promoting its nuclear translocation with EC50 of 1.666 mM.Torin 2(< 50 nM) causes a significant reduction in viability of both MZ-CRC-1 and TT cells. Torin 2 (100 nM) exerts a significant reduction of migration of both MZ-CRC-1 and TT cells. | ||
| 信号通路 | Cell Cycle/DNA Damage PI3K/Akt/mTOR | ||
| 靶 点 | ATM/ATR DNA PK mTOR | ||
结构式
本页面部分数据来自于公开的网络资源,所以瀚香生物不能保证其准确性。
不同批次的产品详情请咨询我们的客服：
- 全国免费电话：400-099-8200
- 在线客服:
瀚香生物（Biochempartner) 的所有产品和服务仅用于科学研究，禁止用于人体和治疗！