Cabozantinib
| CAS No. | 849217-68-1 | Cat. No. | BCP02591 |
| Name | Cabozantinib | ||
| Synonyms | XL 184;XL-184;XL184;BMS-907351;BMS 907351;BMS907351; | ||
| Formula | C28H24FN3O5 | M. Wt | 501.51 |
| Description | XL184 has weak inhibitory activity against RON and PDGFRβ with IC50 of 124 nM and 234 nM, respectivey, and has low activity against FGFR1 with IC50 of 5.294 μM.XL184 at low concentration (0.1-0.5 μM) is sufficient to induce marked inhibition of constitutive and inducible Met phosphorylation and its resultant downstream signaling in MPNST cells, and inhibit HGF-induced MPNST cell migration and invasion. XL184 also induces marked inhibition of Met and VEGFR2 phosphorylation in cytokine-stimulated human umbilical vein endothelial cells (HUVECs). Although XL-184 has no significant effect on MPNST cell growth at 0.1 μM, XL184 at 5-10 μM significantly inhibits the MPNST cell growth. | ||
| Pathways | Angiogenesis/Protein Tyrosine Kinase | ||
| Targets | TAM Receptor VEGFR c Kit FLT3 | ||
Structure
Part data of this page collected from the open network resources, so Biochempartner can not guarantee its accuracy.
For product details of different batches, please contact our Customer
- Service & Tech Support:orders@biochempartner.com
- Website:www.biochempartner.com
Products are for research use only and not for human use. We do not sell to patients.