CP154526

  • Chemical Properties
CAS No. 157286-86-7 Cat. No. BCP26372
Name CP154526
Synonyms CP-154526;CP 154526;CP 154,526; CP-154,526; CP154,526;
Formula C23H32N4 M. Wt 364.53
  • Biological Activity
Description CP 154,526 is a selective, non-peptide CRF1 receptor antagonist (Ki values are 2.7 and > 10000 nM for CRF1 and CRF2 receptors respectively). CP 154,526 blocks CRF-induced adenylate cyclase activation (Ki = 3.7 nM) and attenuates activation of the HPA axis by CRF.
Pathways GPCR/G Protein 
Targets CRFR 

Structure

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