Perifosine
| CAS No. | 157716-52-4 | Cat. No. | BCP00245 |
| Name | Perifosine | ||
| Synonyms | KRX-0401;NSC 639966;D-21266;KRX 0401;KRX0401;D21266;D 21266; | ||
| Formula | C25H52NO4P | M. Wt | 461.66 |
| Description | Perifosine develops anti-proliferative properties with IC50 of 0.6-8.9 μM in immortalized keratinocytes (HaCaT), and head and neck squamous carcinoma cells. [1] Perifosine strongly reduces phosphorylation levels of Akt and extracellular signal-regulated kinase (Erk) 1/2, induces cell cycle arrest in G1 and G2, and causes dose-dependent growth inhibition of mouse glial progenitors. Perifosine (10 μM) completely inhibits the phosphorylation of Akt in MM.1S cells. A recent study demonstrates Per | ||
| Pathways | PI3K/Akt/mTOR | ||
| Targets | AKT | ||
Structure
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