10-Hydroxycamptothecin
| CAS No. | 19685-09-7 | Cat. No. | BCP01385 |
| Name | 10-Hydroxycamptothecin | ||
| Synonyms | (S)-10-Hydroxycamptothecin; 10-HCPT; | ||
| Formula | C20H16N2O5 | M. Wt | 364.35 |
| Description | 10-Hydroxycamptothecin inhibits the growth of BT-20 and MDA-231 cell with IC50 of 34.3 nM and 7.27 nM, respectively, more potently than camptothecin (CPT) with IC50 of >500 nM. 10-Hydroxycamptothecin potently induces human topoisomerase I-mediated cleavable complex formation of pBR322 plasmid DNA with EC50 of 0.35 μM, displaying >50-fold potency than CPT with EC50 of 18.85 μM. 10-Hydroxycamptothecin treatment induces dose-dependent growth inhibition of human microvascular endothelial cells (HMEC | ||
| Related Products | 64439-81-2（10-Hydroxycamptothecin acetate） | ||
| Pathways | Cell Cycle/DNA Damage | ||
| Targets | Topoisomerase | ||
|
Hyperbranched polymer drug delivery treatment for lung metastasis of salivary adenoid cystic carcinoma in nude mice
Publications Citing of Biochempartner's 10-Hydroxycamptothecin(CAS:19685-09-7) |
Structure
Part data of this page collected from the open network resources, so Biochempartner can not guarantee its accuracy.
For product details of different batches, please contact our Customer
- Service & Tech Support:orders@biochempartner.com
- Website:www.biochempartner.com
Products are for research use only and not for human use. We do not sell to patients.