ARRY-543
| CAS No. | 1146629-86-8 | Cat. No. | BCP01646 |
| Name | ARRY-543 | ||
| Synonyms | ARRY543;ARRY 543;Varlitinib tosylate; | ||
| Formula | C22H19ClN6O2S.C7H8O2S.C7H8O2S | M. Wt | 579.07 |
| Description | ARRY334543 is an AKT pathway inhibitor in cells that contains active ErbB-2 receptors. ARRY334543 suppresses ErbB-2 and ErbB-1 phosphorylation in human cancer cells, such as BT-474 with IC50 of 43 nM) and A431 with IC50 of 36 nM) that overexpress ErbB-2 and ErbB-1, respectively. | ||
| Pathways | Angiogenesis/Protein Tyrosine Kinase Jak/Stat Pathway | ||
| Targets | EGFR | ||
Structure
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