LY294002
| CAS号 | 154447-36-6 | 货号 | BCP00195 |
| 中文名 | LY294002 | ||
| 英文名 | LY294002 | ||
| 中文别名 | |||
| 英文别名 | NSC 697286; SF 1101; LY 294002; LY-294002; NSC-697286; SF-1101; NSC697286; SF1101; | ||
| 分子式 | C19H17NO3 | 分子量 | 307.34 |
| 生物活性 | LY294002 is a morpholine derivative of quercetin. It is a potent inhibitor of phosphoinositide 3-kinases (PI3Ks). Two of these are the proto-oncogene serine/threonine-protein kinase (PIM1) and the phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform. With an IC50 of 1.4 uM it is somewhat less potent than wortmannin, another well-known PI3 kinase inhibitor However, LY294002 is a reversible inhibitor of PI3K whereas wortmannin acts irreversibly. Application of LY294002 causes a substantial acceleration of MEPP frequency (150 μM) at the frog neuromuscular junction through a mechanism that is independent of intraterminal calcium. LY294002 causes the release of MEPPs through a perturbation of synaptotagmin function. | ||
| 信号通路 | PI3K/Akt/mTOR | ||
| 靶 点 | PI3K | ||
|
Cerebroprotective Effects of Ginsenoside Rg1 on Rats
with Amyloid β-Protein Induced Alzheimer’s Disease
购于瀚香生物(Biochempartner)的LY294002(CAS:154447-36-6)被引用 |
结构式
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