AG-1478.hcl

CAS No.	170449-18-0	Cat. No.	BCP01312
Name	AG-1478.hcl
Synonyms	Tyrphostin AG-1478;AG 1478;AG1478;Tyrphostin AG 1478;
Formula	C16H15Cl2N3O2.HCl	M. Wt	352.22

Description	AG-1478 preferentially inhibits U87MG cells expressing truncated EGFR with IC50 of 8.7 μM, compared to those expressing endogenous wt EGFR or overexpressing exogenous wt EGFR with IC50 of 34.6 μM and 48.4 μM, respectively, and inhibits the DNA synthesis with IC50 of 4.6 μM, 19.67 μM, and 35.2 μM, respectively. AG-1478 also preferentially inhibits the tyrosine kinase activity and autophosphorylation of the ΔEGFR compared to endogenous or overexpressed exogenous wt EGFR. AG-1478 (0.25 μM) abolishe
Pathways	Angiogenesis/Protein Tyrosine Kinase Jak/Stat Pathway
Targets	PDGFR EGFR

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