Sitagliptin phosphate monohydrate

CAS No.	654671-77-9	Cat. No.	BCP01412
Name	Sitagliptin phosphate monohydrate
Synonyms	Sitagliptin phosphate hydrate;MK-0431 phosphate monohydrate;Sitagliptin Phosphate.H2O;
Formula	C16H18F6N5O5P	M. Wt	523.32

Description	Sitagliptin phosphate monohydrate is a potent inhibitor of DPP4 with IC50 of 19 nM in Caco-2 cell extractsSitagliptin is an oral antihyperglycemic (anti-diabetic drug) of the dipeptidyl peptidase-4 (DPP-4) inhibitor class. It was developed and is marketed by Merck & Co. This enzyme-inhibiting drug is used either alone or in combination with other oral antihyperglycemic agents (such as metformin or a thiazolidinedione) for treatment of diabetes mellitus type 2. The benefit of this medicine is its lower side-effects (e.g., less hypoglycemia, less weight gain) in the control of blood glucose values. Exenatide (Byetta) also works by its effect on the incretin system.
Pathways	Protease/Metabolic Enzyme
Targets	DPP

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