Tandutinib
| CAS No. | 387867-13-2 | Cat. No. | BCP01370 |
| Name | Tandutinib | ||
| Synonyms | MLN518;CT53518;MLN 518;CT 53518;MLN-518;CT-53518; | ||
| Formula | C31H42N6O4 | M. Wt | 562.7 |
| Description | Tandutinib has little activity against EGFR, FGFR, KDR, InsR, Src, Abl, PKC, PKA and MAPKs. Tandutinib inhibits IL-3-independent cell growth and FLT3-ITD autophosphorylation with an IC50 of 10-100 nM. Tandutinib also inhibits the proliferation of human leukemia Ba/F3 cells containing FLT3-ITD mutations with IC50 values of 10-30 nM, and the FLT3-ITD-positive Molm-13 and Molm-14 cells with an IC50 of 10 nM. In FLT3-ITD-positive Molm-14 cells but not the FLT3-ITD-negative THP-1 cells, Tandutinib tre | ||
| Pathways | Angiogenesis/Protein Tyrosine Kinase | ||
| Targets | FLT3 | ||
Structure
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