Oridonin

  • Chemical Properties
CAS No. 28957-04-2 Cat. No. BCP01044
Name Oridonin
Synonyms Isodonol;
Formula C20H28O6 M. Wt 364.43
  • Biological Activity
Description Oridonin effectively inhibites the proliferation of a wide variety of cancer cells including those from prostate (LNCaP, DU145, PC3), breast (MCF-7, MDA-MB231), non-small cell lung (NSCL) (NCI-H520, NCI-H460, NCI-H1299) cancers, acute promyelocytic leukemia (NB4), and glioblastoma multiforme (U118, U138) with ED50s ranging from 1.8 to 7.5 μg/ml. The antitumor activities of Oridonin may due to its inhibitory effects on NF-kappaB and MAPKs signal pathways.
Pathways PI3K/Akt/mTOR 
Targets AKT 

Structure

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