Oridonin
CAS No. | 28957-04-2 | Cat. No. | BCP01044 |
Name | Oridonin | ||
Synonyms | Isodonol; | ||
Formula | C20H28O6 | M. Wt | 364.43 |
Description | Oridonin effectively inhibites the proliferation of a wide variety of cancer cells including those from prostate (LNCaP, DU145, PC3), breast (MCF-7, MDA-MB231), non-small cell lung (NSCL) (NCI-H520, NCI-H460, NCI-H1299) cancers, acute promyelocytic leukemia (NB4), and glioblastoma multiforme (U118, U138) with ED50s ranging from 1.8 to 7.5 μg/ml. The antitumor activities of Oridonin may due to its inhibitory effects on NF-kappaB and MAPKs signal pathways. | ||
Pathways | PI3K/Akt/mTOR | ||
Targets | AKT |
Structure
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