Axitinib
| CAS No. | 319460-85-0 | Cat. No. | BCP01371 |
| Name | Axitinib | ||
| Synonyms | AG-013736;AG 013736;AG013736; | ||
| Formula | C22H18N4OS | M. Wt | 386.47 |
| Description | Axitinib could block the cellular autophosphorylation of VEGFR and VEGF-mediated endothelial cell viability, tube formation, and downstream signaling. Axitinib inhibits the proliferation of variable cell lines with IC50 of >10,000 nM (IGR-N91), 849 nM (IGR-NB8), 274 nM (SH-SY5Y) and 573 nM (non-VEGF stimulated HUVEC). | ||
| Pathways | Angiogenesis/Protein Tyrosine Kinase | ||
| Targets | PDGFR VEGFR | ||
Structure
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