Bafetinib
| CAS No. | 887650-05-7 | Cat. No. | BCP01377 |
| Name | Bafetinib | ||
| Synonyms | INNO-406;INNO406;INNO 406;NS-187;NS 187;NS187; | ||
| Formula | C30H31F3N8O | M. Wt | 576.62 |
| Description | Bafetinib blocks WT Bcr-Abl autophosphorylation and its downstream kinase activity with IC50 of 11 nM and 22 nM in K562 and 293T cells, respectively. Bafetinib suppresses the growth of the Bcr-Abl-positive cell lines including K562, KU812, and BaF3/wt cells potently without effects on the proliferation of the Bcr-Abl-negative U937 cell line. Moreover, Bafetinib exhibits a dose-dependent antiproliferative effect against Bcr-Abl point mutant cell lines, such as BaF3/E255K cells. In Bcr-Abl+ leukemi | ||
| Pathways | Angiogenesis/Protein Tyrosine Kinase | ||
| Targets | Src/Bcr Abl | ||
Structure
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