SB202190
| CAS No. | 152121-30-7 | Cat. No. | BCP00675 |
| Name | SB202190 | ||
| Synonyms | SB 202190;SB-202190;FHPI; | ||
| Formula | C20H14N3OF | M. Wt | 331.34 |
| Description | SB 202190 significantly inhibits both basal and anti-Fas antibody-induced MAPKAPK 2 activity in a dose-dependent manner. SB202190 by itself is sufficient to induce cell death in Jurkat and HeLa cells through activation of CPP32-like caspases, which can be blocked by expression of bcl-2. SB202190-induced apoptosis is attenuated by p38β but augmented by p38α. SB 202190 strongly inhibits UVB induced COX-2 protein expression in HaCaT cells, and markedly inhibits UVB induced cox-2 mRNA. | ||
| Pathways | MAPK Pathway | ||
| Targets | p38 MAPK | ||
Structure
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