SB202190
| CAS号 | 152121-30-7 | 货号 | BCP00675 |
| 中文名 | SB202190 | ||
| 英文名 | SB202190 | ||
| 中文别名 | |||
| 英文别名 | SB 202190;SB-202190;FHPI; | ||
| 分子式 | C20H14N3OF | 分子量 | 331.34 |
| 生物活性 | SB 202190 significantly inhibits both basal and anti-Fas antibody-induced MAPKAPK 2 activity in a dose-dependent manner. SB202190 by itself is sufficient to induce cell death in Jurkat and HeLa cells through activation of CPP32-like caspases, which can be blocked by expression of bcl-2. SB202190-induced apoptosis is attenuated by p38β but augmented by p38α. SB 202190 strongly inhibits UVB induced COX-2 protein expression in HaCaT cells, and markedly inhibits UVB induced cox-2 mRNA. | ||
| 信号通路 | MAPK Pathway | ||
| 靶 点 | p38 MAPK | ||
结构式
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