Fludarabine
| CAS No. | 21679-14-1 | Cat. No. | BCP01383 |
| Name | Fludarabine | ||
| Synonyms | Fludara;HSDB 6964; HSDB6964; HSDB-6964; NSC 118218; NSC118218; NSC-118218; | ||
| Formula | C10H12FN5O4 | M. Wt | 285.23 |
| Description | Fludarabine efficiently inhibits the proliferation of RPMI 8226 cells with IC50 of 1.54 μg/mL. The IC50 of Fludarabine against MM.1S and MM.1R cells is 13.48 μg/mL and 33.79 μg/mL, respectively. In contrast, U266 cells are resistant to Fludarabine with IC50 of 222.2 μg/mL. Fludarabine treatment results in increased number of cells in the G1 phase of cell cycle, accompanied with a concomitant reduction of cells at the S phase of cell cycle in a time-dependent manner. Fludarabine induces a cell cyc | ||
| Pathways | Cell Cycle/DNA Damage Jak/Stat Pathway Wnt/Stem Cell | ||
| Targets | DNA/RNA Synthesis Antimetabolite Stat | ||
Structure
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