Triciribine
| CAS No. | 35943-35-2 | Cat. No. | BCP01849 |
| Name | Triciribine | ||
| Synonyms | API-2; NSC-154020; NSC 154020; NSC154020; TCN; | ||
| Formula | C13H16N6O4 | M. Wt | 320.3 |
| Description | Triciribine is a potent AKT inhibitor and a cell-permeable tricyclic nucleoside molecule with potential antineoplastic activity. Triciribine inhibits the phosphorylation, activation, and signalling of Akt-1, -2, and -3, which may result in the inhibition of Akt-expressing tumor cell proliferation. Akts are anti-apoptotic serine/theronine-specific protein kinases that phosphorylate and inactivate components of the apoptotic machinery, including Bcl-xL/Bcl-2-associated death promoter (BAD) and caspase 9. | ||
| Pathways | Cell Cycle/DNA Damage Microbiology/Virology PI3K/Akt/mTOR | ||
| Targets | DNA/RNA Synthesis HIV AKT | ||
Structure
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