奈拉滨
| CAS号 | 121032-29-9 | 货号 | BCP02093 |
| 中文名 | 奈拉滨 | ||
| 英文名 | Nelarabine | ||
| 中文别名 | |||
| 英文别名 | Arranon;506U7; | ||
| 分子式 | C11H15N5O5 | 分子量 | 297.27 |
| 生物活性 | The IC50 of Nelarabine is 25-fold and 113-fold higher than ARAC in T- and B-lineage, respectively. T-ALL cells are eightfold more sensitive to Nelarabine than B-lineage but there is considerable overlap. The efficacy of NEL in T-lineage and B-lineage cell lines is 25-fold and 113-fold less than ARAC, respectively.Nelarabine acts by inhibiting DNA synthesis and inducing apoptosis in susceptible cells.Nelarabine demonstrated significant antineoplastic activity with acceptable toxicity. | ||
| 信号通路 | Cell Cycle/DNA Damage | ||
| 靶 点 | DNA/RNA Synthesis Antimetabolite | ||
结构式
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