达格列净
| CAS号 | 461432-26-8 | 货号 | BCP01880 |
| 中文名 | 达格列净 | ||
| 英文名 | Dapagliflozin | ||
| 中文别名 | 达格列嗪; | ||
| 英文别名 | BMS-512148;BMS512148;BMS 512148; | ||
| 分子式 | C21H25ClO6 | 分子量 | 408.87 |
| 生物活性 | Dapagliflozin, also known as BMS-512148, is a drug used to treat type 2 diabetes approved in 2012 by FDA. Dapagliflozin inhibits subtype 2 of the sodium-glucose transport proteins (SGLT2) which are responsible for at least 90% of the glucose reabsorption in the kidney. Blocking this transporter mechanism causes blood glucose to be eliminated through the urine. In clinical trials, dapagliflozin lowered HbA1c by 0.6 versus placebo percentage points when added to metformin. | ||
| 信号通路 | Ion Channel/Membrane Transporter GPCR/G Protein | ||
| 靶 点 | SGLT | ||
结构式
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