MLN 8054
| CAS No. | 869363-13-3 | Cat. No. | BCP02261 |
| Name | MLN 8054 | ||
| Synonyms | MLN-8054;MLN8054; | ||
| Formula | C25H15ClF2N4O2 | M. Wt | 476.86 |
| Description | MLN8054 is an ATP-competitive, reversible inhibitor of recombinant Aurora A kinase with an IC50 of 4 nM, which shows >40-fold more selective inhibitory activity for Aurora A compared with Aurora B. [1] In vitro, MLN8054 exhibits the activity of growth inhibition across various cell lines from diverse tissue origins with IC50 values ranging from 0.11 μM to 1.43 μM. In addition, MLN8054 selectively inhibits Aurora A over Aurora B in cultured cells, and inhibits cell proliferation by promoting G2/M accumulation and spindle defects in multiple cultured human tumor cells lines. A recent study shows that MLN8054 sensitizes androgen-resistant prostate cancer to radiation by inhibiting Aurora A kinase, which is associated with sustained DNA double-strand breaks. | ||
| Pathways | Cell Cycle/DNA Damage Epigenetics | ||
| Targets | Aurora | ||
Structure
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