SB203580
| CAS No. | 152121-47-6 | Cat. No. | BCP01763 |
| Name | SB203580 | ||
| Synonyms | SB-203580;SB 203580;RWJ 64809; | ||
| Formula | C21H16FN3OS | M. Wt | 377.43 |
| Description | SB203580 inhibits the IL-2-induced proliferation of primary human T cells, murine CT6 T cells, or BAF F7 B cells with an IC50 of 3–5 μm. SB203580 also inhibits IL-2-induced p70S6 kinase activation, although the concentration required is slightly higher with an IC50 above 10 μm. SB203580 also inhibits the activity of PDK1 in a dose-dependent manner with an IC50 in the 3–10 μm range. SB203580 inhibits p38-MAPK stimulation of MAPKAPK2 with an IC50 of approximately 0.07 μM, whereas inhibits total SAPK/JNK activity with an IC50 of 3–10 μM. SB203580 at higher concentrations activates the ERK pathway, which subsequently enhances NF-κB transcriptional activity. SB203580 induces autophagy in human hepatocellular carcinoma (HCC) cells. | ||
| Pathways | MAPK Pathway | ||
| Targets | p38 MAPK | ||
Structure
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