卡巴他赛
| CAS号 | 183133-96-2 | 货号 | BCP27641 |
| 中文名 | 卡巴他赛 | ||
| 英文名 | Cabazitaxel | ||
| 中文别名 | |||
| 英文别名 | XRP6258; XRP-6258; XRP 6258; TXD 258; TXD-258; TXD258; | ||
| 分子式 | C45H57NO14 | 分子量 | 835.93 |
| 生物活性 | Cabazitaxel increases CYP3A enzyme activities in rat hepatocytes. The mean ex-vivo human plasma protein binding of Cabazitaxel is 91.6%. Cabazitaxel is rapidly and extensively metabolised in numerous metabolites. Cabazitaxel demonstrates activity in several murine and human resistant cell lines.With a 4-day exposure to cabazitaxel, cytotoxicity is noted with relatively low cabazitaxel concentrations. Cabazitaxel shows high antitumor activity in 3 human colorectal cell lines (HCT-116, HCT-8, and HT-29). | ||
| 信号通路 | Ion Channel/Membrane Transporter Neuro Signaling Pathway Cell Cycle/DNA Damage | ||
| 靶 点 | P glycoprotein Microtubule | ||
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Subcellular detection of PEBCA particles in macrophages: combining darkfield microscopy, confocal Raman microscopy, and ToF–SIMS analysis
购于瀚香生物(Biochempartner)的卡巴他赛(CAS:183133-96-2)被引用 |
|
A comparative biodistribution study of polymeric and lipid-based nanoparticles
购于瀚香生物(Biochempartner)的卡巴他赛(CAS:183133-96-2)被引用 |
结构式
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