Alisertib
| CAS No. | 1028486-01-2 | Cat. No. | BCP01823 |
| Name | Alisertib | ||
| Synonyms | MLN 8237;MLN8237;MLN-8237; | ||
| Formula | C27H20ClFN4O4 | M. Wt | 518.94 |
| Description | Alisertib, also known as MLN8237, is a second-generation, orally bioavailable, highly selective small molecule inhibitor of the serine/threonine protein kinase Aurora A kinase with potential antineoplastic activity. Aurora kinase inhibitor MLN8237 binds to and inhibits Aurora A kinase, which may result in disruption of the assembly of the mitotic spindle apparatus, disruption of chromosome segregation, and inhibition of cell proliferation. | ||
| Pathways | Cell Cycle/DNA Damage Epigenetics | ||
| Targets | Aurora | ||
Structure
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